The Download: the most cancers vaccine renaissance, and dealing in the direction of a decarbonized future


Last week, Moderna and Merck launched a big medical trial within the UK of a promising new most cancers remedy: a personalised vaccine that targets a particular set of mutations present in every particular person’s tumor. This examine is enrolling sufferers with melanoma. But the businesses have additionally launched a section III trial for lung most cancers. And earlier this month BioNTech and Genentech introduced {that a} personalised vaccine they developed in collaboration exhibits promise in pancreatic most cancers, which has a notoriously poor survival fee.

Drug builders have been working for many years on vaccines to assist the physique’s immune system struggle most cancers, with out a lot success. But promising outcomes up to now yr counsel that the technique could also be reaching a turning level. Will these therapies lastly reside as much as their promise? Read the total story.

—Cassandra Willyard

This story is from The Checkup, our weekly biotech and well being publication. Sign up to obtain it in your inbox each Thursday.

How we remodel to a totally decarbonized world

Deb Chachra is a professor of engineering at Olin College of Engineering in Needham, Massachusetts, and the writer of How Infrastructure Works: Inside the Systems That Shape Our World

Just as a lot as technological breakthroughs, it’s that availability of vitality that has formed our materials world. The exponential rise in fossil-fuel utilization over the previous century and a half has powered novel, energy-intensive modes of extracting, processing, and consuming matter, at unprecedented scale.

But now, the cumulative environmental, well being, and social impacts of this strategy have change into unignorable. We can see them practically in all places we glance, from the well being results of residing close to highways or oil refineries to the ever-growing challenge of plastic, textile, and digital waste. 

Decarbonizing our vitality techniques means assembly human wants with out burning fossil fuels and releasing greenhouse gases into the ambiance. The excellent news is {that a} world powered by electrical energy from plentiful, renewable, non-polluting sources is now inside attain. Read the total story.



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